Article Correctness Is Author's Responsibility: New Insight Into How Antidepressant Drugs Work

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This is a cartoon of a head and a man standing behind, pulling out string from the brainHippocampal HCN channels are more highly expressed in people with major depressive disorder. Antidepressants that increase cAMP signaling interfere with TRIP8b's ability to bind to HCN channels, helping to restore cognitive ability in those with MDD.